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1

Prodrug-activating systems in suicide gene therapy

Springer, Caroline J., Niculescu-Duvaz, Ion

Journal:

Journal of Clinical Investigation

Year:

2000

Language:

english

File:

PDF, 1.09 MB

english, 2000

2

Definition of chromosome aberrations in testicular germ cell tumor cell lines by 24-color karyotyping and complementary molecular cytogenetic analyses

Brenda M Summersgill, Osman Jafer, Rubin Wang, Hakan Goker, Ioana Niculescu-Duvaz, Robert Huddart, Janet Shipley

Journal:

Cancer Genetics and Cytogenetics

Year:

2001

Language:

english

File:

PDF, 298 KB

english, 2001

3

Novel Inhibitors of B-RAF Based on a Disubstituted Pyrazine Scaffold. Generation of a Nanomolar Lead

Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R., Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J., Davies, Lawrence C., Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

4

Novel Hinge Binder Improves Activity and Pharmacokinetic Properties of BRAF Inhibitors

Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M., Niculescu-Duvaz, Ion, Whittaker, Steven, Niculescu-Duvaz, Dan, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Lopes, Filipa, Preece

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.56 MB

english, 2010

5

Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer

Heyes, James A., Niculescu-Duvaz, Dan, Cooper, Robert G., Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 226 KB

english, 2002

6

Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy

Springer, Caroline J., Dowell, Robert, Burke, Philip J., Hadley, Elma, Davies, D. Huw, Blakey, David C., Melton, Roger G., Niculescu-Duvaz, Ion

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.61 MB

english, 1995

7

Self-Immolative Nitrogen Mustard Prodrugs for Suicide Gene Therapy

Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Friedlos, Frank, Martin, Janet, Spooner, Robert, Davies, Lawrence, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 172 KB

english, 1998

8

A Practical Method of Measuring Glomerular Filtration Rate by Iohexol Clearance Using Dried Capillary Blood Spots

Mafham, Marion M., Niculescu-Duvaz, Ioana, Barron, Jeffrey, Emberson, Jonathan R., Dockrell, Mark E.C., Landray, Martin J., Baigent, Colin

Journal:

Nephron Clinical Practice

Year:

2007

Language:

english

File:

PDF, 222 KB

english, 2007

9

Structure-Activity Relationship in Cationic Lipid Mediated Gene Transfection

D. Niculescu-duvaz, J. Heyes, C. Springer

Year:

2003

Language:

english

File:

PDF, 450 KB

english, 2003

10

ChemInform Abstract: Clomiphene and Tamoxifen Analogues as Potential Non-Steroidal Antiestrogens.

O. STANCIUC, I. NICULESCU-DUVAZ, G. STANCIUC, A. T. BALABAN

Journal:

Year:

1998

File:

PDF, 35 KB

1998

11

Ultrasonically stimulated electron transfer in organic chemistry. Reaction of nitrobenzene with triphenylmethane and its derivatives

M. Vinatoru, A. Iancu, E. Bartha, A. Petride, V. Badescu, D. Niculescu-Duvaz, F. Badea

Journal:

Ultrasonics Sonochemistry

Year:

1994

Language:

english

File:

PDF, 464 KB

english, 1994

12

A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N,N-bis(2-hydroxyethyl)amino]phenyl chloroformate

Dan Niculescu-Duvaz, Ian Scanlon, Ion Niculescu-Duvaz, Caroline J. Springer

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

13

Corrigendum to “A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N,N-bis(2-hydroxyethyl)amino]phenyl chloroformate”: [Tetrahedron Lett. 46 (2005) 6919]

Dan Niculescu-Duvaz, Ian Scanlon, Ion Niculescu-Duvaz, Caroline J. Springer

Journal:

Tetrahedron Letters

Year:

2006

File:

PDF, 44 KB

2006

14

Potential anticancer agents. XIX. New Urethanic Type Nitrogen Mustards Derived from Steroidic Structures

Dr. I. Niculescu-Duvăz, Irina Elian, Mihaela Ionescu, Eutanta Tărnăuceanu

Journal:

Advanced Synthesis & Catalysis

Year:

1979

Language:

english

File:

PDF, 385 KB

english, 1979

15

Potential anticancer agents. XXVIII. Synthesis of Some Cyclohexanone Derived N-Nitrosoureas

Ileana Baracu, Dr. I. Niculescu-Duvaz

Journal:

Advanced Synthesis & Catalysis

Year:

1985

Language:

english

File:

PDF, 370 KB

english, 1985

16

Potential anticancer agents. XXVI. Spin Labelled Nitrosoureas

Ileana Baracu, V. Dobre, Dr. I. Niculescu-Duvaz

Journal:

Advanced Synthesis & Catalysis

Year:

1985

Language:

english

File:

PDF, 495 KB

english, 1985

17

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Bart M.J.M. Suijkerbuijk, Delphine Ménard, Alfonso Zambon, Arnaud Nourry, Lawrence Davies, Helen A. Manne, Frank Friedlos, Lesley Ogilvie, Douglas Hedley, And

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.32 MB

english, 2010

18

Development of an outpatient finger-prick glomerular filtration rate procedure suitable for epidemiological studies

Niculescu-Duvaz, I, D'mello, L, Maan, Z, Barron, J L, Newman, D J, Dockrell, M E C, Kwan, J T C

Journal:

Kidney International

Year:

2006

Language:

english

File:

PDF, 104 KB

english, 2006

19

B-RAF is a therapeutic target in melanoma

Karasarides, Maria, Chiloeches, Antonio, Hayward, Robert, Niculescu-Duvaz, Dan, Scanlon, Ian, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Martin, Jan, Marshall, Christopher J

Journal:

Year:

2004

Language:

english

File:

PDF, 339 KB

english, 2004

20

Introduction to the background, principles, and state of the art in suicide gene therapy

Ion Niculescu-Duvaz, Caroline J. Springer

Journal:

Molecular Biotechnology

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

21

Potential anticancer agents. V. Aromatic nitrogen mustards related to 3-[N,N-bis(2-chloroethyl)amino]-4-methylbenzoic acid

Cambanis, A., Dobre, V., Niculescu-Duvaz, Ion

Journal:

Journal of Medicinal Chemistry

Year:

1969

Language:

english

File:

PDF, 475 KB

english, 1969

22

Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies

Whittaker, S., Kirk, R., Hayward, R., Zambon, A., Viros, A., Cantarino, N., Affolter, A., Nourry, A., Niculescu-Duvaz, D., Springer, C.

Journal:

Science Translational Medicine

Year:

2010

Language:

english

File:

PDF, 1.46 MB

english, 2010

23

ChemInform Abstract: Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT).

C. J. SPRINGER, R. DOWELL, P. J. BURKE, E. HADLEY, D. H. DAVIES, D. C. BLAKEY, R. G. MELTON, I. NICULESCU-DUVAZ

Journal:

Year:

1996

Language:

english

File:

PDF, 35 KB

english, 1996

24

A new clinical candidate for antibody-directed enzyme prodrug therapy (ADEPT): ZD2767

C J. Springer, I. Niculescu-Duvaz, S J. East, R I. Dowell, D H. Davies, P J. Burke, R G. Melton, D C. Blakey

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1995

Language:

english

File:

PDF, 168 KB

english, 1995

25

Small molecule inhibitors of BRAF in clinical trials

Alfonso Zambon, Ion Niculescu-Duvaz, Dan Niculescu-Duvaz, Richard Marais, Caroline J Springer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

26

The EGF Receptor Hokey-Cokey

Dan Niculescu-Duvaz, Steven Whittaker, Caroline Springer, Richard Marais

Journal:

Year:

2007

Language:

english

File:

PDF, 199 KB

english, 2007

27

Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia

Leisl M. Packer, Sareena Rana, Robert Hayward, Thomas O'Hare, Christopher A. Eide, Ana Rebocho, Sonja Heidorn, Matthew S. Zabriskie, Ion Niculescu-Duvaz, Brian J. Druker, Caroline Springer, Richard Ma

Journal:

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

28

Gene-directed enzyme prodrug therapy (GDEPT): choice of prodrugs

C.J. Springer, I. Niculescu-Duvaz

Journal:

Advanced Drug Delivery Reviews

Year:

1996

Language:

english

File:

PDF, 1.20 MB

english, 1996

29

Antibody-directed enzyme prodrug therapy (ADEPT): a review

I Niculescu-Duvaz, C.J Springer

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 1.55 MB

english, 1997

30

TGF-β activates ERK5 in human renal epithelial cells

James Alexander Browne, Alexander L. Pearson, Riad Abou Zahr, Ioana Niculescu-Duvaz, Deborah L. Baines, Mark E.C. Dockrell

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 358 KB

english, 2008

31

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul T.C Wan, Mathew J Garnett, S.Mark Roe, Sharlene Lee, Dan Niculescu-Duvaz, Valerie M Good, Cancer Genome Project, C.Michael Jones, Christopher J Marshall, Caroline J Springer, David Barford, Richa

Journal:

Year:

2004

Language:

english

File:

PDF, 806 KB

english, 2004

32

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumour regressions in colorectal tumour xenografts

D.C. Blakey, P.J. Burke, D.H. Davies, R.I. Dowell, S.J. East, R.G. Melton, I.A. Niculescu-Duvaz, S.K. Sharma, C.J. Springer

Journal:

European Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 123 KB

english, 1997

33

The emerging fields of suicide gene therapy and virotherapy

David Kirn, Ion Niculescu-Duvaz, Gunnel Hallden, Caroline J Springer

Journal:

Trends in Molecular Medicine

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

34

Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)

Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P., Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M., Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Fri

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 208 KB

english, 2009

35

Novel Prodrugs of Alkylating Agents Derived from 2-Fluoro- and 3-Fluorobenzoic Acids for Antibody-Directed Enzyme Prodrug Therapy

Springer, Caroline J., Niculescu-Duvaz, Ion, Pedley, R. Barbara

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.33 MB

english, 1994

36

C-end your drugs using peptide tags

Dan Niculescu-Duvaz, Caroline Springer, Richard Marais

Journal:

Pigment Cell & Melanoma Research

Year:

2010

Language:

english

File:

PDF, 121 KB

english, 2010

37

BRAF Inhibitors Based on an Imidazo[4,5]pyridin-2-one Scaffold and a Meta Substituted Middle Ring

Nourry, Arnaud, Zambon, Alfonso, Davies, Lawrence, Niculescu-Duvaz, Ion, Dijkstra, Harmen P., Ménard, Delphine, Gaulon, Catherine, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M., Friedlos, Frank,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.55 MB

english, 2010

38

Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

Girotti, M. R., Pedersen, M., Sanchez-Laorden, B., Viros, A., Turajlic, S., Niculescu-Duvaz, D., Zambon, A., Sinclair, J., Hayes, A., Gore, M., Lorigan, P., Springer, C., Larkin, J., Jorgensen, C., Ma

Journal:

Cancer Discovery

Year:

2013

Language:

english

File:

PDF, 1.30 MB

english, 2013

39

167 POSTER A pyrazyne scaffold for the generation of novel inhibitors of B-RAF

I. Niculescu-Duvaz, S. Whittaker, F. Friedlos, R. Kirk, I.J. Scanlon, L. Davies, D. Niculescu-Duvaz, E. Roman, R. Marais, C.J. Springer

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 89 KB

english, 2006

40

584 POSTER Novel inhibitors of BRAF based on a 2,6-disubstituted pyrazine scaffold

I. Niculescu-Duvaz, E. Roman, S.R. Whittaker, F. Friedlos, R. Kirk, I.J. Scanlon, L.C. Davies, D. Niculescu-Duvaz, R. Marais, C.J. Springer

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

41

441 The discovery of novel, highly potent inhibitors of BRAF

I. Niculescu-Duvaz, D. Menard, D. Niculescu-Duvaz, A. Zambon, L. Davies, N. Preece, R. Kirk, S. Whittaker, R. Marais, C. Springer

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 62 KB

english, 2010

42

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents

Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.23 MB

english, 2013

43

Potential anticancer agents. IV. Nitrogen mustards of methylbenzoic acids

Niculescu-Duvaz, I., Ionescu, Michaela, Cambanis, A., Vitan, M., Feyns, V.

Journal:

Journal of Medicinal Chemistry

Year:

1968

Language:

english

File:

PDF, 442 KB

english, 1968

44

BRAF as a therapeutic target: a patent review (2006 – 2012)

Zambon, Alfonso, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Marais, Richard, Springer, Caroline J

Journal:

Expert Opinion on Therapeutic Patents

Year:

2013

Language:

english

File:

PDF, 391 KB

english, 2013

45

Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold

Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R., Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J., Davies, Lawrence C., Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 255 KB

english, 2008

46

Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring

Ménard, Delphine, Niculescu-Duvaz, Ion, Dijkstra, Harmen P., Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M., Zambon, Alfonso, Nourry, Arnaud, Roman, Esteban, Davies, Lawrence, Manne, Helen A., Fri

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.67 MB

english, 2009

47

QSAR application in chemical carcinogenesis. II. QSAR analysis of a class of carcinogenesis inhibitor: retinoids

Niculescu-Duvaz, I., Simon, Z., Voiculeţ, N.

Journal:

Year:

1985

Language:

english

File:

PDF, 685 KB

english, 1985

48

Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group

Suijkerbuijk, Bart M. J. M., Niculescu-Duvaz, Ion, Gaulon, Catherine, Dijkstra, Harmen P., Niculescu-Duvaz, Dan, Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A.,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.16 MB

english, 2010

49

Gene-Directed Enzyme Prodrug Therapy

Niculescu-Duvaz, Ion, Spooner, Robert, Marais, Richard, Springer, Caroline J.

Journal:

Bioconjugate Chemistry

Year:

1998

Language:

english

File:

PDF, 357 KB

english, 1998

50

Potential anticancer agents. 17. Analogs of methotrexate with a tripeptide side chain

Suster, Dan Carol, Tarnauceanu, Eutanta, Botez, Georgeta, Dobre, Vasile, Niculescu-Duvaz, Ion

Journal:

Journal of Medicinal Chemistry

Year:

1978

Language:

english

File:

PDF, 350 KB

english, 1978

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